Transdermal Pain—Classes of Drugs:

Home » Transdermal Pain—Classes of Drugs:

Transdermal Pain—Classes of Drugs:



Muscle Relaxor (Cyclobenzaprine, Baclofen)

This is commonly utilized for the relief of muscle spasm associated with acute and or chronic painful musculoskeletal conditions. These drugs inhibit norepinephrine reuptake and facilitates serotonergic system inhibition. The drugs we use are cyclobenzaprine and baclofen. Physicians prescribe these drugs topically to target problems such as muscle spasms, muscle tension, and sports injury.


NMDA Receptor Antagonist (Ketamine)

This is commonly utilized for general anesthetic purposes to prevent pain and discomfort during certain medical procedures, tests, or to treat refractory pain topically. This drug stabilizes magnesium connectivity to NMDA receptor sites preventing magnesium release and subsequent massive depolarizations thus preventing secondary messengers from exciting neighboring neurons. The drug we use in this class is ketamine. Physicians prescribe this drug, topically, to target problems such as chronic regional pain syndrome, post herpetic neuralgia, diabetic peripheral neuropathy, and other general breakthrough pain problems.


Anesthetics (Lidocaine/Prilocaine)

This is commonly used topically and intravenously to treat pain. These drugs block sodium ion channel preventing nerve cell membrane polarization which prevents action potential propagation. The drugs we use in this class are Lidocaine and Prilocaine. Physicians prescribe these drugs topically to target problems such as providing dermal analgesia and to numb the skin area it is applied to.


Neuropathic Agent (Gabapentin and Lamotrigine)

This is commonly used to treat diabetic peripheral neuropathy, post herpetic neuralgia and other neuropathic pain problems. These drugs inhibit voltage-gated calcium channels of vascular smooth muscles which inhibit muscle contraction. The drugs in this class that we use are gabapentin and Lamotrigine. Physicians prescribe these drugs, topically, to target problems such as diabetic peripheral neuropathy, post herpetic neuralgia, and other nerve pain problems.


Tri-Cyclic Anti-Depressant (Amitriptyline)

This is commonly utilized to treat mental/mood problems such as depression. This drug blocks reuptake of serotonin and norepinephrine in the descending pathway which enhances transduction in the synapse. The drug we use in this class is amitriptyline. Physicians prescribe this drug, topically, to target problems such as pain of neuropathic origin, diabetic neuropathy, and to relax the area of treatment.


Lipo-Derm ® Active Max ™

This is our commonly utilized transdermal base which has studies evaluating the percutaneous absorption levels of many analgesic drugs utilized on the market. The study was designed to evaluate the percutaneous absorption pharmacokinetics of these drugs. Absorption was measured in human cadaver skin, in vitro, using the finite dose technique and Franz Diffusion Cells, a specific study design that is the gold standard in the pharmaceutical industry. This study resoundingly demonstrates that Lipo-Derm ® Active Max ™ has the power and reliability compounders and practitioners are looking for. Test results available upon request.